In 1973, the American company PECTON used silicon oil and silica as raw materials to create a gel, which was then packaged in glass test tubes and marketed. In 1982, Japan's Mizuuchi Chemical Industry and its peers replaced glass test tubes with plastic ones, achieving commercialization. In 1991, the Dalian Institute of Chemical Physics of the Chinese Academy of Sciences and the Dalian Clinical Laboratory Center collaborated for the first time in China to develop a domestically produced serum separation gel. This product received attention from the Ministry of Health's Clinical Laboratory Center and proved to meet all standard requirements after clinical application. 

Today, the serum separation gel collection tubes are made from polyester or polypropylene. The serum separation gel is derived from polyolefins, polyesters, and acrylic resins. Coagulants include silica powder, carbonized silica, and snake venom, which are sprayed on the inside of the tube. The separation gel is placed at the bottom of the test tube, and blood samples are added. After blood coagulation, the test tube is centrifuged, causing the separation gel to form an isolation layer between the serum and blood clot. This layer maintains the original state of the serum without alteration. The isolation layer firmly adheres to the inner wall of the test tube, allowing direct serum suction by automated analyzers in their original state or after refrigeration for storage and long-distance transportation without affecting detection results. It also avoids the effects of fibrin and hemolysis. Furthermore, the entire process—from blood sample injection into the collection tube, serum separation, direct serum suction by the analyzer, sample preservation, and waste disposal—is conducted within the same tube, preventing blood sample contamination of operators and reducing the risk of viral infection from blood. This approach also minimizes medical waste and improves work efficiency. 

The serum separation gel and blood clotting accelerant  were independently developed and produced by Improve Medical Technology (Nanxiong) Co., Ltd, which are of stable quality and reasonable price. 
The IMPROVE MEDICAL vacuum blood collection tubes added these two components as additives have passed strict clinical verification and succesfully obtained FDA registration in the United States, this fully proves that they have no impact on test results.